Climate change is a fact; therefore, adaptation to a changing environment is a necessity.Adaptation is ultimately local, yet similar challenges pose themselves to decision-makers all across the globe and on all levels.The Economics of Climate Adaptation (ECA) methodology has established an economic framework to fully integrate risk and reward persp
Evaluation of Fasting Bile Acid Levels in Pregnant Women Diagnosed with Hyperemesis Gravidarum
Background: Hyperemesis gravidarum is a common cause of nausea and vomiting during the early gestational week.At the same time, it can also lead to an increase in liver enzyme values in patients due to or independently of underlying liver disease.This study aimed to evaluate fasting bile acid (FBA) levels, alanine aminotransferase (ALT), aspartate
Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells
Abstract Bis(monoacylglycero)phosphate (BMP) is a major phospholipid constituent of intralumenal membranes in late endosomes/lysosomes, where it regulates the Non-Woven Disc degradation and sorting of lipid cargo.Recent observations suggest that the Batten disease-associated protein CLN5 functions as lysosomal BMP synthase.Here, we show that transa